Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.

Nature genetics - 1 Mar 2001

Pabst T, Mueller B U, Zhang P, Radomska H S, Narravula S, Schnittger S, Behre G, Hiddemann W, Tenen D G

Abstract excerpt

The transcription factor C/EBPalpha (for CCAAT/enhancer binding protein-alpha; encoded by the gene CEBPA) is crucial for the differentiation of granulocytes. Conditional expression of C/EBPalpha triggers neutrophilic differentiation, and no mature granulocytes are observed in Cebpa-mutant mice. Here we identify heterozygous mutations in CEBPA in ten patients with acute myeloid leukemia (AML). We found that five...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-alpha
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Dominant

Share to Granulocytes

Share to In Vitro Techniques

Share to Leukemia, Myeloid, Acute

Share to Neutrophils

Share to Transcriptional Activation

Source

Identifiers

PMID: 11242107
DOI: 10.1038/85820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.PMID 11242107Read ↗

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.Semantic proximity Read ↗

Modeling of C/EBPalpha mutant acute myeloid leukemia reveals a common expression signature of committed myeloid leukemia-initiating cells.Semantic proximity Read ↗

Complexity of CEBPA dysregulation in human acute myeloid leukemia.Semantic proximity Read ↗

[Roles of CEBPA mutation and expression abnormality in acute myeloid leukemia - review].Semantic proximity Read ↗

CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin's lymphoma.Semantic proximity Read ↗

Gain‐of‐Function Effects of N‐Terminal CEBPA Mutations in Acute Myeloid LeukemiaSemantic proximity Read ↗

c-Myc Is a Critical Target for C/EBPα in GranulopoiesisSemantic proximity Read ↗

C/EBPα dysregulation in AML and ALL.Semantic proximity Read ↗

Mutation of CEBPA in familial acute myeloid leukemia.Semantic proximity Read ↗

C/EBPα deregulation as a paradigm for leukemogenesis.Semantic proximity Read ↗

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.Semantic proximity Read ↗

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.