Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Feb 2009

Koschmieder Steffen, Halmos Balazs, Levantini Elena, Tenen Daniel G

Abstract excerpt

While much is known about aberrant pathways affecting cell growth and apoptosis, our understanding of another critical step of neoplastic transformation, differentiation arrest, remains poor. The differentiation-inducing transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is required for proper control of adipogenesis, glucose metabolism, granulocytic differentiation, and lung development....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CCAAT-Enhancer-Binding Protein-alpha
Share to Drug Delivery Systems

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelial Cells

Share to Hematopoietic Stem Cells

Share to Leukemia

Share to Precursor Cell Lymphoblastic Leukemia-Lymphoma

Share to Respiratory System

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 19075268
DOI: 10.1200/JCO.2008.17.9812
PMCID: PMC2645860

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dysregulation of the C/EBPalpha differentiation pathway in human cancer.PMID 19075268Read ↗

Genetic ablation of CCAAT/enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis.Semantic proximity Read ↗

A dominant-negative mutant of C/EBPalpha, associated with acute myeloid leukemias, inhibits differentiation of myeloid and erythroid progenitors of man but not mouse.Semantic proximity Read ↗

Disruption of C/EBPalpha function in acute myeloid leukemia.Semantic proximity Read ↗

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo.Semantic proximity Read ↗

Multiple ways of C/EBPalpha inhibition in myeloid leukaemia.Semantic proximity Read ↗

Repression of transcriptional activity of C/EBPalpha by E2F-dimerization partner complexes.Semantic proximity Read ↗

Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias.Semantic proximity Read ↗

Absence of the transcription factor CCAAT enhancer binding protein α results in loss of myeloid identity in bcr/abl-induced malignancySemantic proximity Read ↗

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia.Semantic proximity Read ↗

Induction of C/EBPα activity alters gene expression and differentiation of human CD34+ cellsSemantic proximity Read ↗

c-Myc Is a Critical Target for C/EBPα in GranulopoiesisSemantic proximity Read ↗

The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.