Construction and characterization of the HMGB1 mutant as a competitive antagonist to HMGB1 induced cytokines release.

doi:10.1016/j.bbrc.2008.05.115

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Article

Construction and characterization of the HMGB1 mutant as a competitive antagonist to HMGB1 induced cytokines release.

Biochemical and biophysical research communications - 8 Aug 2008

Yuan Zhiqiang, Chen Jing, Zhang Yan, Peng Yizhi

Abstract excerpt

Recent studies indicate that the High Mobility Group Box-1 protein (HMGB1) acts as a potent proinflammatory cytokine that contributes to the pathogenesis of diverse inflammatory and infectious disorders. The proinflammatory cytokine activity of HMGB1 has become a therapeutic target. In this study, we cloned the cDNA encoding human HMGB1 and constructed HMGB1 mutants using a one-step opposite direction PCR. The...

Topics

Amino Acid Sequence
Amino Acid Substitution
Anti-Inflammatory Agents
Cell Line
HMGB1 Protein
Humans
Monocytes
Mutation
Recombinant Proteins
Tumor Necrosis Factor-alpha

Source

Open in PubMed

Identifiers

PMID: 18515078
DOI: 10.1016/j.bbrc.2008.05.115

Genes

HMGB1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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