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Article

The HMGB1 (C106A) mutation inhibits IL-10-producing CD19hiFcγRIIbhi B cell expansion by suppressing STAT3 activation in mice.

Frontiers in immunology - 1 Jan 2022

Liu Mengru, Zhou Jingwen, Yin Rui, Yin Hui, Ding Yue, Ma Feng, Qian Li

Abstract excerpt

Regulatory B cells have important roles in inflammation and autoimmune diseases. A newly discovered subpopulation of B cells with a CD19hiFcγRIIbhi phenotype inhibits the proliferation of CD4+ T cells by secreting interleukin (IL)-10. The expansion of CD19hiFcγRIIbhi B cells in mouse spleen can be induced by lipopolysaccharide (LPS) or CpG oligodeoxynucleotide stimulation. However, the mechanism of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35983056
DOI: 10.3389/fimmu.2022.975551
PMCID: PMC9378787

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