Article
Aspirin's Active Metabolite Salicylic Acid Targets High Mobility Group Box 1 to Modulate Inflammatory Responses.
Molecular medicine (Cambridge, Mass.) - 18 Jun 2015
Choi Hyong Woo, Tian Miaoying, Song Fei, Venereau Emilie, Preti Alessandro, Park Sang-Wook, Hamilton Keith, Swapna G V T, Manohar Murli, Moreau Magali, Agresti Alessandra, Gorzanelli Andrea, De Marchis Francesco, Wang Huang, Antonyak Marc, Micikas Robert J, Gentile Daniel R, Cerione Richard A, Schroeder Frank C, Montelione Gaetano T, Bianchi Marco E, Klessig Daniel F
Abstract excerpt
Salicylic acid (SA) and its derivatives have been used for millennia to reduce pain, fever and inflammation. In addition, prophylactic use of acetylsalicylic acid, commonly known as aspirin, reduces the risk of heart attack, stroke and certain cancers. Because aspirin is rapidly de-acetylated by esterases in human plasma, much of aspirin's bioactivity can be attributed to its primary metabolite, SA. Here we...
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