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Emerging roles for HMGB1 protein in immunity, inflammation, and cancer

1 May 2015

Abstract excerpt

High-mobility group box 1 (HMGB1) protein is a member of the highly conserved non-histone DNA binding protein family. First identified in 1973, as one of a group of chromatin-associated proteins with high acidic and basic amino acid content, it was so named for its characteristic rapid mobility in polyacrylamide gel electrophoresis. HMGB1 was later discovered to have another function. It is released from a...

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PMID: 27471716
DOI: 10.2147/itt.s58064

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