Article
Association of HMGB1 polymorphisms with outcome in patients with systemic inflammatory response syndrome.
Critical care (London, England) - 1 Jan 2008
Kornblit Brian, Munthe-Fog Lea, Madsen Hans O, Strøm Jens, Vindeløv Lars, Garred Peter
Abstract excerpt
INTRODUCTION: High mobility group box 1 protein (HMGB1) is a pleiotropic cytokine, recently implicated in the pathophysiology of the systemic inflammatory response syndrome (SIRS) and sepsis. Data from experimental sepsis models show that administration of anti-HMGB1 antibodies significantly decreased mortality, even when administration was delayed for 24 hours, providing a window of opportunity for therapeutic...
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