Article
High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes.
The Journal of experimental medicine - 21 Aug 2000
Andersson U, Wang H, Palmblad K, Aveberger A C, Bloom O, Erlandsson-Harris H, Janson A, Kokkola R, Zhang M, Yang H, Tracey K J
Abstract excerpt
Lipopolysaccharide (LPS) is lethal to animals because it activates cytokine release, causing septic shock and tissue injury. Early proinflammatory cytokines (e.g., tumor necrosis factor [TNF] and interleukin [IL]-1) released within the first few hours of endotoxemia stimulate mediator cascades that persist for days and can lead to death. High mobility group 1 protein (HMG-1), a ubiquitous DNA-binding protein, was...
Topics
- Animals
- Carrier Proteins
- Cells, Cultured
- Chemokine CCL3
- Chemokine CCL4
- Cytokines
- Enzyme-Linked Immunosorbent Assay
- Fluorescent Antibody Technique
- HMGB1 Protein
- High Mobility Group Proteins