Article
High-mobility group box 1 protein induces tissue factor expression in vascular endothelial cells via activation of NF-kappaB and Egr-1.
Thrombosis and haemostasis - 1 Aug 2009
Lv Ben, Wang Haichao, Tang Yiting, Fan Zhang, Xiao Xianzhong, Chen Fangping
Abstract excerpt
High-mobility group box 1 protein (HMGB1), an abundant nuclear protein, was recently established as a proinflammatory mediator of experimental sepsis. Although extracellular HMGB1 has been found in atherosclerotic plaques, its potential role in the pathogenesis of atherothrombosis remains elusive. In the present study, we determined whether HMGB1 induces tissue factor (TF) expression in vascular endothelial cells...
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