Article
Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release.
The Journal of experimental medicine - 27 Aug 2012
Venereau Emilie, Casalgrandi Maura, Schiraldi Milena, Antoine Daniel J, Cattaneo Angela, De Marchis Francesco, Liu Jaron, Antonelli Antonella, Preti Alessandro, Raeli Lorenzo, Shams Sara Samadi, Yang Huan, Varani Luca, Andersson Ulf, Tracey Kevin J, Bachi Angela, Uguccioni Mariagrazia, Bianchi Marco E
Abstract excerpt
Tissue damage causes inflammation, by recruiting leukocytes and activating them to release proinflammatory mediators. We show that high-mobility group box 1 protein (HMGB1) orchestrates both processes by switching among mutually exclusive redox states. Reduced cysteines make HMGB1 a chemoattractant, whereas a disulfide bond makes it a proinflammatory cytokine and further cysteine oxidation to sulfonates by...
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