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Article

High mobility group box protein 1 in complex with lipopolysaccharide or IL-1 promotes an increased inflammatory phenotype in synovial fibroblasts.

Arthritis research & therapy - 26 Aug 2011

Wähämaa Heidi, Schierbeck Hanna, Hreggvidsdottir Hulda S, Palmblad Karin, Aveberger Anne-Charlotte, Andersson Ulf, Harris Helena Erlandsson

Abstract excerpt

INTRODUCTION: In addition to its direct proinflammatory activity, extracellular high mobility group box protein 1 (HMGB1) can strongly enhance the cytokine response evoked by other proinflammatory molecules, such as lipopolysaccharide (LPS), CpG-DNA and IL-1β, through the formation of complexes. Extracellular HMGB1 is abundant in arthritic joint tissue where it is suggested to promote inflammation as...

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Source

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Identifiers

PMID: 21871094
DOI: 10.1186/ar3450
PMCID: PMC3239379

Genes

HMGB1
TNF
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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