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Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenes

2019-10-08

Abstract excerpt

High-mobility group box 1 (HMGB1) is a damage-associated molecular pattern with key proinflammatory functions following tissue injury. Moreover, HMGB1 neutralization was shown to alleviate LPS-induced shock, suggesting a role for the protein as a master therapeutic target for inflammatory and infectious diseases. Here, we report that HMGB1 neutralization impedes immune responses to Listeria monocytogenes , a wide...

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Literature Corpus work
e9574e84-0a47-51bc-851e-03632adb5254
DOI
10.1101/797902
Open publication

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Leukocyte-derived High-mobility group box 1 controls innate immune responses against Listeria monocytogenesDOI 10.1101/797902
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