Article
Mutations in the AXIN1 gene in advanced prostate cancer.
European urology - 1 Sept 2009
Yardy George W, Bicknell David C, Wilding Jennifer L, Bartlett Sylvia, Liu Ying, Winney Bruce, Turner Gareth D H, Brewster Simon F, Bodmer Walter F
Abstract excerpt
BACKGROUND: The Wnt signalling pathway directs aspects of embryogenesis and is thought to contribute to maintenance of certain stem cell populations. Disruption of the pathway has been observed in many different tumour types. In bowel, stomach, and endometrial cancer, this is usually due to mutation of genes encoding Wnt pathway components APC or beta-catenin. Such mutations are rare in hepatocellular carcinomas...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.