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Detection and analysis of ?-catenin mutations in prostate cancer

1 Jan 2000

Abstract excerpt

BACKGROUND: E-cadherin and alpha-catenin are components of adherens junctions which mediate calcium-dependent, cell-cell adhesion in a homotypic manner. Both these molecules have been defined as useful tumor markers as their altered expression correlates with increased tumor aggressiveness and dedifferentiation. More recently, alterations of a third component of adherens junctions, beta-catenin, have been...

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PMID: 11102958
DOI: 10.1002/1097-0045(20001201)45:4<323::aid-pros7>3.0.co;2-w

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