Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate Cancer

6 Oct 2015

Abstract excerpt

The Wnt/β-catenin signaling pathway has been identified as one of the predominantly upregulated pathways in castration-resistant prostate cancer (CRPC). However, whether targeting the β-catenin pathway will prove effective as a CRPC treatment remains unknown. Polo-like kinase 1 (Plk1) is a critical regulator in many cell cycle events, and its level is significantly elevated upon castration of mice carrying...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related gene regulation
Share to Prostate Cancer Treatment and Research
Share to Wnt/β-catenin signaling in development and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 26438599
DOI: 10.1128/mcb.00825-15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cotargeting Polo-Like Kinase 1 and the Wnt/β-Catenin Signaling Pathway in Castration-Resistant Prostate CancerPMID 26438599Read ↗

Exploring the Wnt Pathway as a Therapeutic Target for Prostate CancerSemantic proximity Read ↗

Activation of beta-catenin signaling in prostate cancer by peptidyl-prolyl isomerase Pin1-mediated abrogation of the androgen receptor-beta-catenin interaction.Semantic proximity Read ↗

Combination therapies with Wnt signaling inhibition: A better choice for prostate cancer treatmentSemantic proximity Read ↗

β-Catenin Is Required for Prostate Development and Cooperates with Pten Loss to Drive Invasive CarcinomaSemantic proximity Read ↗

Rare histologic transformation of a CTNNB1 (β-catenin) mutated prostate cancer with aggressive clinical course.Semantic proximity Read ↗

Next-generation Sequencing of Advanced Prostate Cancer Treated with Androgen-deprivation TherapySemantic proximity Read ↗

PIM1 kinase as a target in prostate cancer: roles in tumorigenesis, castration resistance, and docetaxel resistance.Semantic proximity Read ↗

δ-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profilesSemantic proximity Read ↗

Targeting CHD1L suppresses prostate cancer progression via the FOXO3-PUMA axisSemantic proximity Read ↗

Targeting Plk1 to Enhance Efficacy of Olaparib in Castration-Resistant Prostate Cancer.Semantic proximity Read ↗

Polo-like Kinase 1 Facilitates Loss of Pten Tumor Suppressor-induced Prostate Cancer FormationSemantic proximity Read ↗

Wnt signaling and prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.