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Article

Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling

17 Sept 2019

Abstract excerpt

BACKGROUND: Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a member of WAVE complex and actin cytoskeleton regulator and adaptor protein, acts as tumor suppressor in prostate cancer but the role of ABI1 in EMT is not clear. METHODS: To investigate the...

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Share to Prostate Cancer Treatment and Research
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PMID: 31530281
DOI: 10.1186/s12964-019-0410-y

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