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Article

Inactivation of Apc in the mouse prostate causes prostate carcinoma.

Cancer research - 15 Mar 2007

Bruxvoort Katia J, Charbonneau Holli M, Giambernardi Troy A, Goolsby James C, Qian Chao-Nan, Zylstra Cassandra R, Robinson Daniel R, Roy-Burman Pradip, Shaw Aubie K, Buckner-Berghuis Bree D, Sigler Robert E, Resau James H, Sullivan Ruth, Bushman Wade, Williams Bart O

Abstract excerpt

Alterations of the Wnt/beta-catenin signaling pathway are positively associated with the development and progression of human cancer, including carcinoma of the prostate. To determine the role of activated Wnt/beta-catenin signaling in mouse prostate carcinogenesis, we created a mouse prostate tumor model using probasin-Cre-mediated deletion of Apc. Prostate tumors induced by the deletion of Apc have elevated...

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Identifiers

PMID: 17363566
DOI: 10.1158/0008-5472.CAN-06-3028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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