Article
Roles and regulation of Wnt signaling and beta-catenin in prostate cancer.
Cancer letters - 8 Jun 2006
Verras Meletios, Sun Zijie
Abstract excerpt
The Wnt signaling pathway and its key component beta-catenin play critical roles in embryonic development as well as in human diseases, including various malignancies. Accumulated evidence has demonstrated a significant role for the Wnt pathway in the development and progression of human prostate cancer. The recent discovery of an interaction between beta-catenin and the androgen receptor (AR) suggests a possible...
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