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Article

<i>Dlk1</i> Influences Differentiation and Function of <i>β</i> Lymphocytes

1 Jun 2008

Abstract excerpt

The Dlk1 (delta-like-1) gene is a member of the epidermal growth factor (EGF)-like homeotic gene family. It influences cell-cell interactions between stromal cells and pro-B cells in vitro. To define the in vivo role of the dlk protein in B cell development, we established a Dlk1-/- mouse model. In spleens of Dlk1-/- mice, transitional B cell numbers were increased and the ratio between transitional B cell...

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Identifiers

PMID: 18513163
DOI: 10.1089/scd.2007.0102

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