Article
B-1 B cell progenitors transiently and partially express keratin 5 during differentiation in bone marrow.
Journal of dermatological science - 1 Mar 2016
Hanafusa Takaaki, Kato Kenichi, Azukizawa Hiroaki, Miyazaki Jun-ichi, Takeda Junji, Katayama Ichiro
Abstract excerpt
BACKGROUND: Keratin 5 (K5) is a cytoskeletal tissue-specific protein expressed in the epithelial cells of skin and esophagus and ectopic K5 expression in lymphocytes has never been reported. OBJECTIVE: Here we demonstrate an ectopic epidermal self-protein expression in B-1 B cell by fate mapping of K5-expressing cells. METHODS: K5-Cre×CAG-CAT-loxP-EGFP double Tg (K5×GFP) mice that express enhanced GFP under the...
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