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Article

Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2015

Wu Ying-Yu, Georg Ina, Díaz-Barreiro Alejandro, Varela Nieves, Lauwerys Bernard, Kumar Ramesh, Bagavant Harini, Castillo-Martín Mireia, El Salem Fadi, Marañón Concepción, Alarcón-Riquelme Marta E

Abstract excerpt

Polymorphisms in the B lymphoid tyrosine kinase (BLK) gene have been associated with autoimmune diseases, including systemic lupus erythematosus, with risk correlating with reduced expression of BLK. How reduced expression of BLK causes autoimmunity is unknown. Using Blk(+/+) , Blk(+/-) , and Blk(-/-) mice, we show that aged female Blk(+/-) and Blk(-/-) mice produced higher anti-dsDNA IgG Abs and developed immune...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25972485
DOI: 10.4049/jimmunol.1402736
PMCID: PMC4458437

Genes

BLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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