Article
Altered Marginal Zone B Cell Selection in the Absence of IκBNS.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2018
Ádori Monika, Pedersen Gabriel K, Ádori Csaba, Erikson Elina, Khoenkhoen Sharesta, Stark Julian M, Choi Jin Huk, Dosenovic Pia, Karlsson Mikael C I, Beutler Bruce, Karlsson Hedestam Gunilla B
Abstract excerpt
Marginal zone (MZ) B cells reside in the splenic MZ and play important roles in T cell-independent humoral immune responses against blood-borne pathogens. IκBNS-deficient bumble mice exhibit a severe reduction in the MZ B compartment but regain an MZ B population with age and, thus, represent a valuable model to examine the biology of MZ B cells. In this article, we characterized the MZ B cell defect in further...
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