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Article

B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.

Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2014

Pedersen Gabriel K, Àdori Monika, Khoenkhoen Sharesta, Dosenovic Pia, Beutler Bruce, Karlsson Hedestam Gunilla B

Abstract excerpt

B-1 cells mediate early protection against infection by responding to T cell-independent (TI) antigens found on the surface of various pathogens. Mice with impaired expression of the atypical IκB protein IκBNS have markedly reduced frequencies of B-1 cells. We used a mouse strain with dysfunctional IκBNS derived from an N-ethyl-N-nitrosourea (ENU) screen, named bumble, to investigate the point in the development...

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Identifiers

PMID: 25228759
DOI: 10.1073/pnas.1415866111
PMCID: PMC4191775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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