Article
B-1a transitional cells are phenotypically distinct and are lacking in mice deficient in IκBNS.
Proceedings of the National Academy of Sciences of the United States of America - 30 Sept 2014
Pedersen Gabriel K, Àdori Monika, Khoenkhoen Sharesta, Dosenovic Pia, Beutler Bruce, Karlsson Hedestam Gunilla B
Abstract excerpt
B-1 cells mediate early protection against infection by responding to T cell-independent (TI) antigens found on the surface of various pathogens. Mice with impaired expression of the atypical IκB protein IκBNS have markedly reduced frequencies of B-1 cells. We used a mouse strain with dysfunctional IκBNS derived from an N-ethyl-N-nitrosourea (ENU) screen, named bumble, to investigate the point in the development...
Topics
- Adoptive Transfer
- Animals
- Animals, Newborn
- Antigens, T-Independent
- B-Lymphocyte Subsets
- Cell Differentiation
- I-kappa B Proteins
- Immunoglobulin M
- Intracellular Signaling Peptides and Proteins
- Mice
- Mice, Inbred C57BL
- Mice, Knockout