Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet Homeostasis

6 Feb 2020

Abstract excerpt

Genes of the Notch signaling pathway are expressed in different cell types and organs at different time points during embryonic development and adulthood. The Notch ligand Delta-like 1 (DLL1) controls the decision between endocrine and exocrine fates of multipotent progenitors in the developing pancreas, and loss of Dll1 leads to premature endocrine differentiation. However, the role of Delta-Notch signaling in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital heart defects research
Share to Genetic Syndromes and Imprinting
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32029480
DOI: 10.2337/db19-0795

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet HomeostasisPMID 32029480Read ↗

NEUROD1 Is Required for the Early α and β Endocrine Differentiation in the PancreasSemantic proximity Read ↗

Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.Semantic proximity Read ↗

LIM domain–binding 1 maintains the terminally differentiated state of pancreatic β cellsSemantic proximity Read ↗

Murine Perinatal β-Cell Proliferation and the Differentiation of Human Stem Cell–Derived Insulin-Expressing Cells Require NEUROD1Semantic proximity Read ↗

Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes.Semantic proximity Read ↗

Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors.Semantic proximity Read ↗

<i>Dlk1</i> expression marks developing endothelium and sites of branching morphogenesis in the mouse embryo and placentaSemantic proximity Read ↗

The imprinted gene Delta like non-canonical notch ligand 1 (Dlk1) associates with obesity and triggers insulin resistance through inhibition of skeletal muscle glucose uptakeSemantic proximity Read ↗

Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in Hlxb9-deficient mice.Semantic proximity Read ↗

The SNAG Domain of Insm1 Regulates Pancreatic Endocrine Cell Differentiation and Represses β- to δ-Cell Transdifferentiation.Semantic proximity Read ↗

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.Semantic proximity Read ↗

The role of delta-like non-canonical Notch ligand 1 (DLK1) in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.