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Article

A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.

Proceedings of the National Academy of Sciences of the United States of America - 31 Jul 2012

Arnold Carrie N, Pirie Elaine, Dosenovic Pia, McInerney Gerald M, Xia Yu, Wang Nathaniel, Li Xiaohong, Siggs Owen M, Karlsson Hedestam Gunilla B, Beutler Bruce

Abstract excerpt

Using chemical germ-line mutagenesis, we screened mice for defects in the humoral immune response to a type II T-independent immunogen and an experimental alphavirus vector. A total of 26 mutations that impair humoral immunity were recovered, and 19 of these mutations have been positionally cloned. Among the phenovariants were bumble, cellophane, and Worker ascribed to mutations in Nfkbid, Zeb1, and Ruvbl2,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22761313
DOI: 10.1073/pnas.1209134109
PMCID: PMC3411946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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