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Article

Protonation state of glutamate 73 regulates the formation of a specific dimeric association of mVDAC1.

Proceedings of the National Academy of Sciences of the United States of America - 9 Jan 2018

Bergdoll Lucie A, Lerch Michael T, Patrick John W, Belardo Kendrick, Altenbach Christian, Bisignano Paola, Laganowsky Arthur, Grabe Michael, Hubbell Wayne L, Abramson Jeff

Abstract excerpt

The voltage-dependent anion channel (VDAC) is the most abundant protein in the outer mitochondrial membrane and constitutes the primary pathway for the exchange of ions and metabolites between the cytosol and the mitochondria. There is accumulating evidence supporting VDAC's role in mitochondrial metabolic regulation and apoptosis, where VDAC oligomerization has been implicated with these processes. Herein, we...

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Identifiers

PMID: 29279396
DOI: 10.1073/pnas.1715464115
PMCID: PMC5777057

Genes

VDAC1

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