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Article

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis.

The Journal of cell biology - 2 Jun 2008

Minter-Dykhouse Katherine, Ward Irene, Huen Michael S Y, Chen Junjie, Lou Zhenkun

Abstract excerpt

The importance of the DNA damage response (DDR) pathway in development, genomic stability, and tumor suppression is well recognized. Although 53BP1 and MDC1 have been recently identified as critical upstream mediators in the cellular response to DNA double-strand breaks, their relative hierarchy in the ataxia telangiectasia mutated (ATM) signaling cascade remains controversial. To investigate the divergent and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18504301
DOI: 10.1083/jcb.200801083
PMCID: PMC2396806

Genes

MDC1
ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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