Article
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Nature - 27 Feb 2003
Stewart Grant S, Wang Bin, Bignell Colin R, Taylor A Malcolm R, Elledge Stephen J
Abstract excerpt
To counteract the continuous exposure of cells to agents that damage DNA, cells have evolved complex regulatory networks called checkpoints to sense DNA damage and coordinate DNA replication, cell-cycle arrest and DNA repair. It has recently been shown that the histone H2A variant H2AX specifically controls the recruitment of DNA repair proteins to the sites of DNA damage. Here we identify a novel BRCA1...
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