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Functional defects of cancer-associated MDC1 mutations in DNA damage repair.

DNA repair - 1 Jun 2022

Xie Rong, Yan Zhenzhen, Jing Ju, Wang Yukun, Zhang Jiajia, Li Yipeng, Liu Xiuhua, Yu Xiaochun, Wu Chen

Abstract excerpt

Mediator of DNA damage checkpoint protein 1 (MDC1) serves as a docking platform to promote the localization of various DNA damage response (DDR) components to DNA double-strand break (DSB) sites. MDC1 is vital in controlling proper DDR and maintaining genomic stability. In cancers, genomic instability results from mutations in DNA repair genes and drives cancer development. The mutations of MDC1 in human cancers...

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PMID: 35378404
DOI: 10.1016/j.dnarep.2022.103330

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