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Article

Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice.

International journal of cancer - 15 Mar 2009

Chi Ya-Hui, Ward Jerrold M, Cheng Lily I, Yasunaga Junichiro, Jeang Kuan-Teh

Abstract excerpt

The spindle assembly checkpoint (SAC) guards against chromosomal missegregation during mitosis. To investigate the role of SAC in tumor development, mice heterozygously knocked out for the mitotic arrest deficient (Mad) genes Mad1 and/or Mad2 were mated with p53(+/) (-) mice. Increased tumor frequencies were reproducibly observed in Mad2(+/) (-)p53(+/) (-) (88.2%) and Mad1(+/) (-)Mad2(+/) (-)p53(+/) (-) (95.0%)...

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Identifiers

PMID: 19065665
DOI: 10.1002/ijc.24094
PMCID: PMC2706662

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Source receipt: pubmed, retrieved 7 Sept 2026.

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