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53BP1-mediated activation of the tumor suppressor p53

7 Sept 2024

Abstract excerpt

In recent years, the role of 53BP1 as a cell cycle regulator has come into the spotlight. 53BP1 is best understood for its role in controlling DNA double-strand break repair. However, 53BP1 was initially discovered as an interaction partner of the tumor suppressor p53, which proved to be independent of DNA repair. The importance of this interaction is becoming increasingly clear. 53BP1 responds to mitotic stress,...

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PMID: 39244835
DOI: 10.1016/j.ceb.2024.102424

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