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Article

p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice.

Molecular and cellular biology - 1 Apr 2003

Ward Irene M, Minn Kay, van Deursen Jan, Chen Junjie

Abstract excerpt

53BP1 is a p53 binding protein of unknown function that binds to the central DNA-binding domain of p53. It relocates to the sites of DNA strand breaks in response to DNA damage and is a putative substrate of the ataxia telangiectasia-mutated (ATM) kinase. To study the biological role of 53BP1, we disrupted the 53BP1 gene in the mouse. We show that, similar to ATM(-/-) mice, 53BP1-deficient mice were growth...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12640136
DOI: 10.1128/MCB.23.7.2556-2563.2003
PMCID: PMC150747

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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