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Article

Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair.

Molecular cell - 28 Dec 2007

Xie Anyong, Hartlerode Andrea, Stucki Manuel, Odate Shobu, Puget Nadine, Kwok Amy, Nagaraju Ganesh, Yan Catherine, Alt Frederick W, Chen Junjie, Jackson Stephen P, Scully Ralph

Abstract excerpt

Phosphorylated histone H2AX ("gamma-H2AX") recruits MDC1, 53BP1, and BRCA1 to chromatin near a double-strand break (DSB) and facilitates efficient repair of the break. It is unclear to what extent gamma-H2AX-associated proteins act in concert and to what extent their functions within gamma-H2AX c...

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Topics

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor p53-Binding Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 18158901
DOI: 10.1016/j.molcel.2007.12.005
PMCID: PMC2275782

Genes

MDC1
BRCA1
XRCC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18158901-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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