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Article

Roles for MDC1 in cancer development and treatment.

DNA repair - 1 Nov 2020

Ruff Sophie E, Logan Susan K, Garabedian Michael J, Huang Tony T

Abstract excerpt

The DNA damage response (DDR) is necessary to maintain genome integrity and prevent the accumulation of oncogenic mutations. Consequently, proteins involved in the DDR often serve as tumor suppressors, carrying out the crucial task of keeping DNA fidelity intact. Mediator of DNA damage checkpoint 1 (MDC1) is a scaffold protein involved in the early steps of the DDR. MDC1 interacts directly with γ-H2AX, the...

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Identifiers

PMID: 32866776
DOI: 10.1016/j.dnarep.2020.102948
PMCID: PMC7669677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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