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Article

The mouse-equivalent of the human BDNF VAL66MET polymorphism increases dorsal hippocampal volume and does not interact with developmental ethanol exposure.

Alcohol (Fayetteville, N.Y.) - 1 Aug 2020

Bird Clark W, Barber Megan J, Martin Jack, Mayfield Jacob J, Valenzuela C Fernando

Abstract excerpt

A relatively common polymorphism in the human brain-derived neurotrophic factor (BDNF) gene (Val66Met, which corresponds to Val68Met in mice) has been shown to modulate cognitive function and vulnerability to mental health disorders. This substitution impairs trafficking and activity-dependent release of BDNF. A number of studies with both humans and transgenic mice suggest that carriers of the Met allele have...

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Identifiers

PMID: 32224221
DOI: 10.1016/j.alcohol.2020.03.005
PMCID: PMC7292775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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