Article
Transcriptome profiling analysis of the mechanisms underlying the BDNF Val66Met polymorphism induced dysfunctions of the central nervous system.
Hippocampus - 1 Jan 2014
Wang Dong-Dong, Tian Tian, Dong Qing, Xu Xu-Feng, Yu Hui, Wang Yue, Chen Zhe-Yu
Abstract excerpt
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism affects postnatal behaviors and is associated with a variety of neuropsychiatric disorders. However, the mechanisms underlying the BDNF(Met) variant induced dysfunctions of the central nervous system remain obscure. In order to identify the candidate genes and pathways responsible for the dysfunctions associated with this BDNF variation, we analyzed...
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