Article
[Effect of DNA supercoiling on transcription performed by normal and mutant Escherichia coli RNA-polymerases].
Molekuliarnaia biologiia - 1 Jan 2000
Mirkin S M, Bogdanova E S, Gorlenko AhM, Gragerov A I, Larionov O A
Abstract excerpt
A specific DNA-gyrase, inhibitor, coumermycin A1, causes differential changes in the spectrum of proteins synthesized in E. coli wild types cells, while protein spectrum in the mutant cells with coumermycin-resistant DNA-gyrase is left unaffected. The mutation of RNA-polymerase RpoB265 lowers the sensitivity of bacteria to coumermycin A1, whereas the RpoC3 enhances it. The differences between the normal and...
Topics
- Anti-Bacterial Agents
- Coumarins
- DNA, Superhelical
- DNA-Directed RNA Polymerases
- Escherichia coli
- Kinetics
- Mutation
- Pyrroles
- Species Specificity
- Topoisomerase II Inhibitors
- Transcription, Genetic