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Article

Influence of recA mutations on gyrA dependent quinolone resistance.

Biochimie - 1 Apr 1991

Urios A, Herrera G, Aleixandre V, Blanco M

Abstract excerpt

We examined, in Escherichia coli, the influence of recA mutant alleles on the level of quinolone resistance promoted by mutations in the gyrA gene. We found that the recA142 mutation, abolishing all the activities of RecA protein, greatly reduced the level of resistance to the quinolone ciprofloxacin, whereas the recA430 allele affecting the SOS inducing ability of RecA, reduced ciprofloxacin resistance to a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 1655054
DOI: 10.1016/0300-9084(91)90123-i

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Influence of recA mutations on gyrA dependent quinolone resistance.PMID 1655054Read ↗

Effect of RecA inactivation on quinolone susceptibility and the evolution of resistance in clinical isolates of Escherichia coliSemantic proximity Read ↗

Effect of recA inactivation on mutagenesis of Escherichia coli exposed to sublethal concentrations of antimicrobials.Semantic proximity Read ↗

Expression of the recA gene is reduced in Escherichia coli topoisomerase I mutants.Semantic proximity Read ↗

Function of the SOS process in repair of DNA damage induced by modern 4-quinolones.Semantic proximity Read ↗

Opposing effects of aminocoumarins and fluoroquinolones on the SOS response and adaptability in Staphylococcus aureusSemantic proximity Read ↗

New mutations in and around the L2 disordered loop of the RecA protein modulate recombination and/or coprotease activity.Semantic proximity Read ↗

A class of gyrase mutants of Salmonella typhimurium show quinolone-like lethality and require rec functions for viability.Semantic proximity Read ↗

Inhibition of mutation and combating the evolution of antibiotic resistance.Semantic proximity Read ↗

Overexpression of SOS genes in ciprofloxacin resistant Escherichia coli mutants.Semantic proximity Read ↗

Impact of recA on levofloxacin exposure-related resistance development.Semantic proximity Read ↗

Genetic analysis of the requirements for SOS induction by nalidixic acid in Escherichia coli.Semantic proximity Read ↗

Study of the contribution of active defense mechanisms to ciprofloxacin tolerance in Escherichia coli growing at different rates.Semantic proximity Read ↗

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