Article
Influence of recA mutations on gyrA dependent quinolone resistance.
Biochimie - 1 Apr 1991
Urios A, Herrera G, Aleixandre V, Blanco M
Abstract excerpt
We examined, in Escherichia coli, the influence of recA mutant alleles on the level of quinolone resistance promoted by mutations in the gyrA gene. We found that the recA142 mutation, abolishing all the activities of RecA protein, greatly reduced the level of resistance to the quinolone ciprofloxacin, whereas the recA430 allele affecting the SOS inducing ability of RecA, reduced ciprofloxacin resistance to a...
Topics
- DNA Repair
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Escherichia coli
- Genes, Bacterial
- Mutation
- Quinolones
- Rec A Recombinases
- SOS Response, Genetics