Article
Chromosome aberrations and telomere length modulation in bone marrow and spleen cells of melphalan-treated p53+/- mice.
Environmental and molecular mutagenesis - 1 Jul 2008
Sgura Antonella, De Amicis Andrea, Stronati Laura, Cinelli Serena, Pacchierotti Francesca, Tanzarella Caterina
Abstract excerpt
The p53 gene regulates cell cycle and apoptotic pathways after induction of DNA damage. Telomeres, capping chromosome ends, are involved in maintaining chromosome stability; alterations of their length have been related to increased levels of chromosomal aberrations. To study a possible interaction between chromosome aberrations, telomere dysfunction, and p53, we investigated via painting analysis the induction...
Topics
- Animals
- Antineoplastic Agents, Alkylating
- Bone Marrow Cells
- Cells, Cultured
- Chromosome Aberrations
- Chromosome Painting
- Female
- Genotype
- In Situ Hybridization, Fluorescence
- Melphalan
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Spleen