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Article

Melphalan-induced DNA damage in p53(+/-) and wild type mice analysed by the comet assay.

Mutation research - 4 Jun 2004

Cordelli Eugenia, Cinelli Serena, Lascialfari Antonella, Ranaldi Roberto, Pacchierotti Francesca

Abstract excerpt

Melphalan is an alkylating substance used as a therapeutic agent; its mutagenicity is related to its ability to produce monoadducts and to form DNA cross-links. The alkaline comet assay is a useful test for the detection of DNA lesions. However, cross-links are not easily detected under standard conditions. Recently, modifications to the test have been introduced to measure cross-links by evaluating the reduction...

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Source

Identifiers

PMID: 15135647
DOI: 10.1016/j.mrfmmm.2004.02.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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