Article
Chromosome changes caused by alterations of p53 expression.
Mutation research - 5 Jul 1996
Agapova L S, Ilyinskaya G V, Turovets N A, Ivanov A V, Chumakov P M, Kopnin B P
Abstract excerpt
It has been proposed that p53 tumor-suppressor plays a key role in maintaining genome integrity in mammalian cells. We analyzed karyotype alterations in human and murine cell sublines expressing various exogenous human mutant (His175, Trp248, His273) or wild-type (wt) p53 cDNAs. In human pseudodi...
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