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Article

Spontaneous and ionizing radiation-induced chromosomal abnormalities in p53-deficient mice.

Cancer research - 1 Sept 1995

Bouffler S D, Kemp C J, Balmain A, Cox R

Abstract excerpt

Chromosomal abnormalities have been assessed in p53-deficient mice. The in vivo frequency of spontaneous stable aberrations in bone marrow cells was elevated by approximately 20-fold in p53 nulls and 13-fold in p53 heterozygotes compared to wild-type. No excessive induction of stable aberrations by gamma-irradiation was observed, but p53 deficiency resulted in excess radiation-induced hyperploidy (> 10-fold...

Topics

Aneuploidy
Animals
Bone Marrow
Chromatids
Chromosome Aberrations
Genes, p53
Genotype
Karyotyping
Mice
Radiation, Ionizing
Sister Chromatid Exchange

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Identifiers

PMID: 7641208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7641208-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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