Article
Impact of ionizing radiation and genetic background on mammary tumorigenesis in p53-deficient mice.
Cancer research - 1 Sept 2001
Backlund M G, Trasti S L, Backlund D C, Cressman V L, Godfrey V, Koller B H
Abstract excerpt
Loss of p53 function is known to compromise cell cycle regulation, inductionof apoptosis, and DNA damage repair and can facilitate neoplastic transformation of cells. Mutations in the p53 gene are identified frequently in breast carcinomas. Li-Fraumeni patients inheriting a mutant p53 allele have an increased risk for developing tumors including breast cancer. Although mouse lines carrying mutations in the p53...
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