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Article

Recombination at chromosomal sequences involved in leukaemogenic rearrangements is differentially regulated by p53.

Carcinogenesis - 1 Aug 2004

Boehden Gisa S, Restle Anja, Marschalek Rolf, Stocking Carol, Wiesmüller Lisa

Abstract excerpt

Chromosomal translocations and retroviral integration events at breakpoint cluster regions (bcrs) have been associated with leukaemias. To directly compare the effect of different cis-regulatory sequences on recombination, we adapted our SV40 based model system to the analysis of correspondingly selected bcrs from the TAL1, LMO2, retinoic acid receptor alpha (RARalpha) and MLL genes. We show that a 399 bp...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14742315
DOI: 10.1093/carcin/bgh092

Genes

LMO2
TAL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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