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Article

Dynamics of delayed p53 mutations in mice given whole-body irradiation at 8 weeks.

International journal of radiation oncology, biology, physics - 1 Jan 2011

Okazaki Ryuji, Ootsuyama Akira, Kakihara Hiroyo, Mabuchi Yo, Matsuzaki Yumi, Michikawa Yuichi, Imai Takashi, Norimura Toshiyuki

Abstract excerpt

PURPOSE: Ionizing irradiation might induce delayed genotoxic effects in a p53-dependent manner. However, a few reports have shown a p53 mutation as a delayed effect of radiation. In this study, we investigated the p53 gene mutation by the translocation frequency in chromosome 11, loss of p53 alleles, p53 gene methylation, p53 nucleotide sequence, and p53 protein expression/phosphorylation in p53(+/+) and p53(+/-)...

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Source

Identifiers

PMID: 20932652
DOI: 10.1016/j.ijrobp.2010.07.022

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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