Article
p53 mutations, methylation and genomic instability in the progression of chronic myeloid leukaemia.
Leukemia & lymphoma - 1 Jul 1997
Guinn B A, Mills K I
Abstract excerpt
In chronic myeloid leukaemia (CML), as with other tumour types, mutations of the p53 gene are associated with disease progression. Changes in regional methylation of DNA with CML tumour development have also been demonstrated. Methylation is one mechanism by which gene expression is controlled an...
Topics
- Animals
- DNA Methylation
- DNA, Neoplasm
- Disease Progression
- Genes, p53
- Genome
- Genome, Human
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Mutation