Article
Different impact of p53 and p21 on the radiation response of mouse tissues.
Oncogene - 3 Aug 2000
Komarova E A, Christov K, Faerman A I, Gudkov A V
Abstract excerpt
Mammalian tissues differ dramatically in their sensitivity to genotoxic stress, although the mechanisms determining these differences remain largely unknown. To analyse the role of p53 and p21 in determination of tissue specificity to DNA damage in vivo, we compared the effects of gamma radiation on DNA synthesis on whole-body sections of wild type, p53-deficient and p21-deficient mice. A dramatic reduction in...
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