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Article

Telomere shortening is associated with malformation in p53-deficient mice after irradiation during specific stages of development.

DNA repair - 15 Aug 2005

Bekaert Sofie, Derradji Hanane, De Meyer Tim, Michaux Arlette, Buset Jasmine, Neefs Mieke, Mergeay Max, Jacquet Paul, Van Oostveldt Patrick, Baatout Sarah

Abstract excerpt

The natural ends of linear chromosomes, the telomeres, recruit specific proteins in the formation of protective caps that preserve the integrity of the genome. Unprotected chromosomes induce DNA damage checkpoint cascades and ultimately lead to senescence both in mouse and man in a p53 dependent manner and initial telomere length setting therefore determines the proliferative capacity of each cell. Yet, only...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15990362
DOI: 10.1016/j.dnarep.2005.05.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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