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Article

Regulation of diacylglycerol production and protein kinase C stimulation during sperm‐ and PLCζ‐mediated mouse egg activation

12 May 2008

Abstract excerpt

BACKGROUND INFORMATION: At fertilization in mammalian eggs, the sperm induces a series of Ca(2+) oscillations via the production of inositol 1,4,5-trisphosphate. Increased inositol 1,4,5-trisphosphate production appears to be triggered by a sperm-derived PLCzeta (phospholipase C-zeta) that enters the egg after gamete fusion. The specific phosphatidylinositol 4,5-bisphosphate hydrolytic activity of PLCzeta implies...

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PMID: 18471090
DOI: 10.1042/bc20080033

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