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Article

The role and mechanism of action of sperm PLC-zeta in mammalian fertilisation

23 Oct 2017

Abstract excerpt

At mammalian fertilisation, the fundamental stimulus that triggers oocyte (egg) activation and initiation of early embryonic development is an acute rise of the intracellular-free calcium (Ca2+) concentration inside the egg cytoplasm. This essential Ca2+ increase comprises a characteristic series of repetitive Ca2+ oscillations, starting soon after sperm–egg fusion. Over the last 15 years, accumulating scientific...

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PMID: 29061915
DOI: 10.1042/bcj20160521

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